LIQMIX™ INSIDE

NEPHOS — Liquid-to-Gas Mixer

Liquid-to-Gas Standard Generator — from % to ppb

AlySoft™ software — unified control, sequences, analyzer sync and full Audit Trail.

NEPHOS is a liquid-to-gas mixer that generates precise gas-phase calibration standards directly from liquid sources — the standard solution for VOCs, alcohols, water vapour and semi-volatile compounds that are unavailable or unstable in gas cylinders. It operates standalone or combined with a GasMix™ system, controlled via AlySoft™ with full traceability and ISO 6145-7 compliance

NEPHOS — How a Liquid-to-Gas Mixer Works

NEPHOS is AlyTech’s latest evolution in the LiqMix™ range — a bench solution that produces custom gas standards directly from pure or mixed liquids. Optional cascade dilution unlocks an exceptionally wide concentration span, from percent down to ppb.

The instrument precisely vaporizes up to two liquid phases into a controlled carrier gas stream, generating mixtures on demand with full traceability. A modular architecture lets your system evolve as requirements grow — ideal for QA/QC, method development and analyzer validation.

Heated transfer paths up to the delivery point prevent re-condensation, ensuring a clean, stable gas phase for accurate, repeatable measurements.

Direct Coriolis metering — measured mass, not estimated volume

NEPHOS meters every liquid with a Coriolis mass flow meter — it measures the true mass delivered, independent of the liquid’s density, viscosity, temperature or conductivity. That means accurate, repeatable standards across pure liquids and complex mixtures alike, with no re-tuning when you change fluid.

Density-independent: Switch solvents without re-calibrating the dosing.

Real-time verification: liquid and gas flows are monitored continuously, so the produced concentration is known at every instant.

Two simultaneous liquid channels for genuine multi-component standards.

Sulfinert®-treated wetted paths for reactive and corrosive compounds.

Technical Specifications

Everything the NEPHOS delivers, at a glance.

💧 Liquid & Gas Channels
Liquid channels1 or 2 (simultaneous mixing)
Liquid flow (Coriolis)0.5–5 g/h  |  0.5–200 g/h
Gas channels1 to 6
Compatible liquidsPure liquids or liquid mixtures (water, organic solvents) — particle-free
Gas compatibilityPure gases, concentrated mixtures, most aggressive gases
🎯 Mixing & Dilution
Concentration rangefrom % down to ppb
Dilution factorup to 10⁸
Output flow accuracy< 2 % of measured flow *
Output concentration accuracy< 2 %
Accuracy & Traceability
StandardISO 6145-7 compliant
CalibrationMFC & Coriolis factory-calibrated, NIST-traceable
Metrology featuresAutomatic uncertainty calculation, certificate issuance, Audit Trail
Anti-corrosionSulfinert®-treated wetted paths
Pressure & Connections
Gas inlet pressurestable between 3 and 8 bar(g)
Outlet pressureatmospheric (higher possible)
Heated line2m heated output line standard (other lengths available)
ConnectionsSwagelok® 1/16″, 1/8″ & 1/4″
Interface & Power
SoftwareAlySoft™ on Windows 10 or higher, Ethernet communication
Power supply90–260 VAC, 1.5–4 A, 50–60 Hz
Physical
Dimensions (L × W × H)50 × 47 × 58 cm
Weight25–40 kg (depends on configuration)

* When MFCs operate between 10 % and 100 % of full-scale flow.

Software & Automation for the NEPHOS Liquid-to-Gas System

NEPHOS combines a Coriolis-type liquid flow meter with a precisely regulated vaporization chamber. Mass Flow Controllers (MFC) deliver repeatable dilutions, while heated lines maintain the gas phase to the outlet.

Unified control of liquid and gas flows with AlySoft™ software

User-defined sequences for vaporization, dilution and calibration

Real-time monitoring, safety rules and event logging

Synchronization with GC, spectrometers and gas analyzers

Audit Trail for complete traceability

Nephos schematics

Key Benefits

On-Demand Standards

Create calibration gases from liquids and liquid mixtures, instantly.

% → ppb Coverage

Cascade dilution spans an exceptionally wide concentration range.

Coriolis Accuracy

Direct mass metering, density-independent, no re-tuning per fluid.

Traceable by Design

Automatic uncertainty, certificates and Audit Trail in AlySoft™.

Stable Gas Phase

Heated lines prevent re-condensation to the point of delivery.

Modular & Serviceable

Add liquid or gas channels and options as your needs evolve.

Applications

NEPHOS enables on-demand standards for calibration, validation and research from volatile organics to humidity and siloxanes.

Biogas & Siloxanes

Generate siloxane standards to assess silicone-related contaminants.

Filter & Sensor Testing

Ethanol/phenol vapors for carbon filter studies; humidity standards for sensor validation.

Trace VOC & Research

BTEX and other VOC mixes for LOD/LOQ, linearity and hysteresis checks.

Emissions & CEMS

Humid, reactive-compound standards for analyzer checks and validation routines.

Why choose NEPHOS for liquid-to-gas standards?

How NEPHOS compares to conventional peristaltic / syringe-pump generators.

GasMix™NEPHOS Pump-based generators
Liquid meteringCoriolis mass flow — direct massPeristaltic / syringe pump — volumetric
Fluid changeNo re-tuning (density-independent)Often requires recalibration per fluid
Stated accuracy< 2 % concentration, ISO 6145-7Frequently unspecified
Uncertainty & certificateAuto-calculated, issued per pointRarely provided
Range% → ppb, up to 10⁸ dilutionModel-dependent
SystemOne modular, upgradable instrumentMultiple separate models
Humidity / water vapourSupported — high accuracy on aqueous standardsSupported — optimized for long-run stability

FAQ — NEPHOS

Most asked questions about liquid-to-gas standard generation, traceability and daily operation.

NEPHOS covers a very wide range, from percent-level vapors down to trace and ppb levels. When equipped with optional cascade dilution, the overall dilution factor can reach up to 108, depending on configuration and application.

NEPHOS is suitable for many organic solvents and VOC mixtures (e.g. BTEX, siloxanes, alcohols, phenols) and, in dedicated configurations, water or aqueous solutions. Final compatibility depends on volatility, viscosity and material compatibility; our team can review your liquid list and propose the appropriate configuration.

No, NEPHOS is designed to generate gas standards directly from liquids using a carrier gas. It can also be combined with existing gas standards or GasMix™ platforms when you want to mix liquid-derived components with gas-phase standards in the same stream.

Vaporization takes place in a controlled, heated chamber and the transfer path to the outlet is heated to maintain the gas phase. This minimizes the risk of condensation, especially for higher-boiling components, and improves repeatability at low concentrations.

Yes, on request NEPHOS can be built with inert-grade wetted materials (SS316, inert coatings, Kalrez® seals) for aggressive or reactive compounds. For highly corrosive or unusual chemistries, we recommend providing details so we can check material compatibility and lifetime.

NEPHOS relies on 400-point calibrated MFCs, NIST-traceable references and LiqMix™ software. The software calculates concentrations, manages sequences, logs all critical events in an Audit Trail and can generate certificates including calculated concentrations and uncertainties for QA/QC documentation.

A typical installation requires electrical power, a suitable carrier gas supply (e.g. nitrogen, air or other matrices depending on your application) and proper ventilation or exhaust according to the compounds used. Exact requirements are specified in the technical documentation.

Yes. LiqMix™ can synchronize sequences with GC, preconcentrators, spectrometers and other gas analyzers using digital I/O and timing parameters. This allows fully automated calibration routines with minimal operator intervention.

Yes. NEPHOS generates traceable, reactive-compound and humid standards suitable for analyzer checks and validation in emission-monitoring workflows. Tell us your components and regulatory framework and we’ll confirm the configuration.

NEPHOS meters liquids with a Coriolis mass flow meter, measuring true mass independent of density, viscosity or temperature — so you can change fluids without re-tuning. It states a &lt; 2 % concentration accuracy, is ISO 6145-7 compliant, and issues a certificate with uncertainty for every point. Many peristaltic or syringe-pump generators dose by volume and do not publish an accuracy figure.

Yes. NEPHOS vaporizes water and aqueous solutions to generate humid calibration gas alongside your target compounds. Its design prioritizes certified concentration accuracy; for applications requiring very long-duration humidity stability, contact us to confirm the right configuration.

A Coriolis meter measures the actual mass of liquid delivered, unaffected by the fluid’s density, viscosity, temperature or conductivity. This means accurate, repeatable standards across different solvents and mixtures without recalibrating the dosing each time you change liquid — an advantage volumetric pumps cannot match.

Ready to Generate Standards on Demand?

Bring traceable liquid-to-gas calibration to your bench powered by AlySoft.

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